Ramipril 10mg + Hydrochlorothiazide 12.5mg Tablets combine two blood pressure-lowering medicines — ramipril, an ACE inhibitor, and hydrochlorothiazide, a thiazide diuretic — in a single tablet. This combination is used to treat high blood pressure in patients whose condition is already managed using both medicines together, at these same respective doses.
This tablet contains two active substances: ramipril, which belongs to a group of medicines called ACE inhibitors (Angiotensin Converting Enzyme inhibitors), and hydrochlorothiazide, a thiazide diuretic, often referred to as a "water tablet." Each ingredient lowers blood pressure through a different mechanism.
This fixed-dose combination is generally prescribed for patients who have already been stabilised on ramipril and hydrochlorothiazide taken separately at matching doses, offering a more convenient single-tablet option rather than starting treatment from scratch.
Ramipril 10mg + Hydrochlorothiazide 12.5mg may be prescribed to:
Treat high blood pressure (hypertension) in patients already stabilised on ramipril 10mg and hydrochlorothiazide 12.5mg taken concurrently as separate medicines
The appropriate treatment and dose should be determined by a healthcare professional based on individual health needs.
The two active ingredients act on blood pressure through complementary mechanisms. Ramipril blocks an enzyme involved in producing a substance that narrows blood vessels, allowing the vessels to relax and easing the workload on the heart.
Hydrochlorothiazide works on the kidneys, helping the body remove excess salt and water through urine, which reduces the overall volume of fluid in the blood vessels.
Together, these actions support more effective blood pressure control than either medicine alone. The blood pressure-lowering effect of ramipril generally becomes apparent within one to two hours of a dose, while hydrochlorothiazide's fluid-related effects usually develop over several days to a few weeks of regular use.
Take Ramipril + Hydrochlorothiazide exactly as prescribed by your healthcare professional.
Usually taken once daily, generally in the morning
Can generally be taken with or without food
Swallow the tablet whole with a sufficient amount of liquid; do not chew or crush it
Do not stop or change your dose without medical advice, as your blood pressure may rise again if treatment is stopped without guidance
If you miss a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the one missed.
Before taking Ramipril + Hydrochlorothiazide, tell your doctor or pharmacist about your full medical history and all medicines, supplements, and herbal products you currently use.
Caution may be needed if you have, or have had:
Kidney or liver problems
Narrowing of the arteries supplying the kidneys or heart
Low blood pressure or a tendency to feel faint on standing
Diabetes or gout
Recent significant fluid or salt loss (for example, from vomiting, diarrhoea, or excessive sweating)
Abnormal potassium, sodium, or calcium levels shown on blood tests
Ramipril + Hydrochlorothiazide may interact with other medicines that affect blood pressure or electrolyte levels, including other diuretics, potassium supplements, lithium, certain pain relievers (such as NSAIDs), and some diabetes medicines. It is important to check possible interactions with your doctor or pharmacist before starting treatment.
Ramipril + Hydrochlorothiazide should not be used during pregnancy, particularly from the second trimester onward, as it may cause serious harm to the developing baby. It is also generally not recommended during breastfeeding. Recommendations may vary between countries, so speak with your doctor or pharmacist promptly if you are pregnant, breastfeeding, think you may be pregnant, or are planning a pregnancy, so that alternative treatment can be considered in advance.
Like all medicines, Ramipril + Hydrochlorothiazide can cause side effects, although not everyone experiences them.
Common side effects may include:
Dry, persistent cough
Dizziness or headache, particularly at the start of treatment
Tiredness
Low blood pressure, especially when standing up quickly
Changes in blood electrolyte levels (such as potassium or sodium), which may be picked up on routine blood tests
Seek prompt medical attention if you experience swelling of the face, lips, tongue, or throat with difficulty breathing or swallowing, severe skin reactions, or signs of significant dehydration such as severe dizziness or reduced urination.
This is not a complete list of side effects or warnings. Please refer to the product packaging and patient information leaflet supplied with your medicine for complete information and speak with your doctor or pharmacist if you have concerns.
Store Ramipril + Hydrochlorothiazide according to the instructions shown on the original product packaging.
Keep in the original packaging
Keep out of reach and sight of children
Do not use after the expiry date shown on the packaging
Hydrochlorothiazide helps the body eliminate excess salt and water, which complements ramipril's blood-vessel-relaxing effect and can improve blood pressure control when ramipril alone isn't enough.
Yes, especially in the first few weeks, since hydrochlorothiazide is a diuretic. This effect often lessens as your body adjusts.
Your doctor may periodically check kidney function and electrolyte (such as potassium and sodium) levels, since both components can affect these.
It can contribute to fluid and electrolyte loss, particularly in hot weather, with reduced fluid intake, or alongside vomiting or diarrhoea. Speak with your doctor if this applies to you.
Morning is often preferred, since the diuretic effect may otherwise disrupt sleep with more frequent urination — though your doctor's specific instructions should be followed.
Thiazide diuretics can raise uric acid levels and may affect gout. Tell your doctor if you have a history of gout before starting.
