This contains two medicines, both of which help to control high blood pressure. It lowers the blood pressure by relaxing the blood vessels and making it easier for your heart to pump blood around your body. This will reduce your risk of having a heart attack or a stroke.
Losartan 50mg + Amlodipine 5mg Tablets combine two blood pressure-lowering medicines — losartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker — in a single tablet. This combination is used to treat high blood pressure in adults, particularly when blood pressure is not adequately controlled with either medicine alone.
This tablet contains two active substances: losartan, which belongs to a class of medicines called angiotensin II receptor blockers (ARBs), and amlodipine, which belongs to a class of medicines called calcium antagonists (calcium channel blockers). Each ingredient lowers blood pressure through a different mechanism.
This fixed-dose combination is generally prescribed for adults with mild to moderate hypertension that has not responded sufficiently to either medicine used alone, or it may be used to replace the two medicines when they have already been titrated to matching doses as separate tablets.
Losartan 50mg + Amlodipine 5mg may be prescribed to:
Treat mild to moderate high blood pressure (hypertension) in adults
Manage hypertension that has not responded adequately to treatment with a calcium channel blocker or an angiotensin II receptor blocker used alone
The appropriate treatment and dose should be determined by a healthcare professional based on individual health needs.
The two active ingredients lower blood pressure through complementary mechanisms. Losartan blocks the effects of angiotensin II, a natural substance that tightens blood vessels, allowing the vessels to relax and widen. Amlodipine blocks calcium channels in the smooth muscle of blood vessel walls, which also causes the vessels to relax and widen, making it easier for blood to flow and for the heart to pump.
Together, these actions generally provide more effective blood pressure control than either medicine alone. As with most blood pressure medicines, the full effect develops with regular use over time, and individual response can vary.
Take Losartan + Amlodipine exactly as prescribed by your healthcare professional.
Usually taken once daily
Can generally be taken with or without food
Take at the same time each day to help maintain a consistent effect
Do not stop or change your dose without medical advice, as high blood pressure often has no symptoms and stopping treatment may allow it to rise again unnoticed
If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose, in which case skip the missed dose and continue as normal. Do not take a double dose to make up for the one missed.
Before taking Losartan + Amlodipine, tell your doctor or pharmacist about your full medical history and all medicines, supplements, and herbal products you currently use.
Caution may be needed if you have, or have had:
Liver or kidney problems, including narrowing of the arteries supplying the kidneys
Narrowing of the aortic heart valve (aortic stenosis)
Unstable angina or cardiogenic shock
High potassium levels shown on blood tests
Significant fluid or salt loss
Losartan + Amlodipine may interact with other blood pressure medicines, potassium-sparing diuretics or potassium supplements, and certain medicines that affect liver enzyme activity. It is important to check possible interactions with your doctor or pharmacist before starting treatment.
Losartan + Amlodipine should not be taken during pregnancy, as ARB-containing medicines may cause serious harm to the developing baby, particularly in the second and third trimesters. It is also generally not recommended while breastfeeding. Recommendations may vary between countries, so speak with your doctor or pharmacist promptly if you are pregnant, breastfeeding, think you may be pregnant, or are planning a pregnancy.
Like all medicines, Losartan + Amlodipine can cause side effects, although not everyone experiences them.
Common side effects may include:
Dizziness or drowsiness
Headache
Swelling of the ankles or feet
Flushing
Tiredness
Palpitations
Nausea or stomach discomfort
Nasal congestion
Seek prompt medical attention if you experience signs of a severe allergic reaction, significant changes in the amount of urine you pass, a very low or irregular heartbeat, or fainting.
This is not a complete list of side effects or warnings. Please refer to the product packaging and patient information leaflet supplied with your medicine for complete information and speak with your doctor or pharmacist if you have concerns.
Store Losartan + Amlodipine according to the instructions shown on the original product packaging.
Keep in the original packaging
Keep out of reach and sight of children
Do not use after the expiry date shown on the packaging
They lower blood pressure through different mechanisms, so combining them can offer more effective control for some patients than either medicine alone, while simplifying the dosing routine.
Losartan can raise blood potassium levels, particularly if combined with potassium supplements or certain other medicines. Your doctor may monitor this with periodic blood tests.
A persistent dry cough is more commonly linked to a different class of blood pressure medicines (ACE inhibitors) than to losartan, though it can occur occasionally. Mention any ongoing cough to your doctor.
No. Losartan-containing medicines are not suitable during pregnancy, as they may cause serious harm to an unborn baby. Speak with your doctor immediately if you are or may become pregnant.
It's best avoided, as grapefruit juice may reduce losartan's effectiveness in some people.
Your doctor may periodically check kidney function and blood potassium levels, since both losartan and amlodipine can affect these over time.
