Glimepiride 1 mg + Metformin 1000 mg tablets are an oral antidiabetic combination medicine used to help manage blood glucose levels in adults with type 2 diabetes mellitus. Glimepiride stimulates insulin release from the pancreas, while metformin reduces glucose production in the liver and improves the body's response to insulin.
Glimepiride 1 mg + Metformin 1000 mg is a combination medicine containing glimepiride, a sulfonylurea, and metformin, a biguanide. These medicines help lower blood glucose through different mechanisms.
This combination may be prescribed to improve blood glucose control alongside dietary measures and physical activity when both active ingredients are considered appropriate. The suitability of the medicine depends on individual treatment needs, kidney function and other medical factors.
Glimepiride 1 mg + Metformin 1000 mg tablets may be prescribed to:
Help manage blood glucose levels in adults with type 2 diabetes mellitus.
Improve glycaemic control alongside an appropriate diet and regular physical activity.
Support diabetes management when treatment with both glimepiride and metformin is clinically appropriate.
The appropriate treatment and dose should be determined by a healthcare professional based on blood glucose levels, kidney function, medical history and other medicines being used.
Glimepiride stimulates beta cells in the pancreas to release insulin, which helps move glucose from the bloodstream into the body's cells. This action can lower blood glucose but may also cause hypoglycaemia, or low blood sugar.
Metformin primarily reduces glucose production in the liver and improves the body's sensitivity to insulin. It also reduces intestinal glucose absorption to a lesser extent.
Together, these medicines help regulate blood glucose through complementary mechanisms. The extent and timing of improvement vary between individuals and are assessed through blood glucose monitoring and tests such as HbA1c.
Take Glimepiride + Metformin exactly as prescribed by your healthcare professional.
Timing: Glimepiride is generally taken with breakfast or the first main meal. Follow the prescribed schedule for your specific combination product.
With food: Take the tablet with a meal as directed. This can help reduce digestive side effects associated with metformin and support appropriate use of glimepiride.
Administration: Swallow the tablet according to the product instructions. Do not split or crush it unless the product information confirms this is appropriate.
Missed dose: Follow the instructions in the patient information leaflet or ask your pharmacist. Do not take a double dose to compensate for a missed dose.
Treatment changes: Do not stop treatment or change the dose without consulting your healthcare professional.
Follow your prescribed meal plan and blood glucose monitoring schedule, as irregular food intake can increase the risk of low blood sugar while taking glimepiride.
Tell your doctor or pharmacist about your medical history and all medicines, vitamins, supplements and herbal products you use before starting Glimepiride + Metformin.
Particular caution is required in people with:
Kidney impairment: Reduced kidney function can increase the risk of metformin accumulation and lactic acidosis. Kidney function should be assessed before and during treatment.
Liver disease: Liver impairment may increase treatment-related risks and requires medical evaluation.
Previous episodes of low blood sugar: Glimepiride can cause hypoglycaemia, particularly when meals are missed, calorie intake is inadequate or physical activity increases.
Heart failure, severe infection or dehydration: These conditions may affect kidney function or oxygen delivery to tissues and increase the risk of complications associated with metformin.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Glimepiride may increase the risk of haemolytic anaemia in affected individuals.
Heavy alcohol consumption: Alcohol can increase the risk of hypoglycaemia and metformin-associated lactic acidosis.
Important interactions may occur with insulin and other blood glucose-lowering medicines, certain antifungal medicines such as miconazole, corticosteroids, and medicines that affect kidney function or glucose regulation. Iodinated contrast used in some imaging procedures may also require a review of metformin treatment.
Seek urgent medical attention for symptoms that may indicate severe hypoglycaemia or lactic acidosis, including loss of consciousness, unusual weakness, muscle pain, abdominal discomfort or rapid or difficult breathing.
Check possible interactions and precautions with your doctor or pharmacist before starting or stopping any medicine.
Pregnancy: Diabetes treatment may need to be changed before or during pregnancy. Glimepiride may pose a risk to the developing baby, and sulfonylurea treatment can cause low blood sugar in newborns. If you are pregnant, planning a pregnancy or think you may be pregnant, consult your doctor promptly about the most appropriate treatment.
Breastfeeding: Glimepiride may pose a risk of low blood sugar in a breastfed infant, while metformin can pass into breast milk in small amounts. The suitability of this combination during breastfeeding depends on individual circumstances and local prescribing guidance. Consult your doctor before using this medicine while breastfeeding.
Like all medicines, Glimepiride + Metformin can cause side effects, although not everyone experiences them.
Common or recognised side effects may include:
Low blood sugar (hypoglycaemia), which may cause sweating, shaking, dizziness, hunger or confusion.
Headache.
Nausea or vomiting.
Diarrhoea.
Abdominal discomfort.
Loss of appetite.
A metallic taste in the mouth.
Seek urgent medical attention for severe or persistent low blood sugar, loss of consciousness, serious allergic reactions, or symptoms that may indicate lactic acidosis, such as unusual weakness, muscle pain, abdominal pain or difficulty breathing.
This is not a complete list of side effects or warnings. Please refer to the product packaging and patient information leaflet supplied with your medicine for complete information and speak with your doctor or pharmacist if you have concerns.
Store Glimepiride + Metformin according to the instructions shown on the original product packaging.
Keep the tablets in their original packaging where appropriate.
Protect the medicine from heat, moisture and direct light as directed on the packaging.
Keep out of reach of children.
Do not use the medicine after its expiry date.
Ask a pharmacist how to dispose of unused or expired tablets.
It is an oral antidiabetic combination medicine prescribed to help manage blood glucose levels in adults with type 2 diabetes mellitus. It combines two active ingredients that lower blood glucose through different mechanisms.
Both ingredients begin acting after a dose, but the time needed to achieve the desired blood glucose control varies. Your healthcare professional can assess your response through blood glucose readings and longer-term tests such as HbA1c.
Yes, this combination is generally taken with meals as directed by the prescriber. Taking metformin with food can help reduce digestive discomfort, while taking glimepiride as directed with a meal helps manage the risk of low blood sugar.
The timing depends on the prescribed regimen and the specific product. Glimepiride is generally taken with breakfast or the first main meal of the day. Follow the instructions provided by your healthcare professional.
A generic product contains the active ingredients stated on its label at the specified strengths. Whether it can be substituted for a particular branded product depends on the approved formulation and applicable regulatory requirements. Check the product packaging or ask a pharmacist if you are unsure.
Do not stop taking the medicine solely because your blood glucose readings improve. Better readings may reflect the benefits of treatment, dietary changes and physical activity. Discuss any changes to your treatment with your healthcare professional.
Low blood sugar may cause sweating, shaking, dizziness, hunger or confusion. Follow your prescribed hypoglycaemia management plan and seek urgent medical assistance if symptoms are severe, persistent or accompanied by loss of consciousness. Do not give food or drink to someone who is unconscious.
