EPLERENONE 25MG

Short Description

Eplerenone 25 mg is used to treat certain cardiovascular conditions, including heart failure following a heart attack. It blocks aldosterone, a hormone that regulates sodium and potassium balance, helping manage blood pressure and reduce fluid retention.

What Is Eplerenone 25mg?

Eplerenone 25 mg contains eplerenone, a selective mineralocorticoid receptor antagonist that blocks the action of aldosterone.

It is used to improve outcomes in eligible patients with heart failure and reduced pumping function following a heart attack. In some countries, eplerenone is also approved for treating high blood pressure. Approved indications vary by market.

Uses

Eplerenone 25 mg may be prescribed to:

• Improve survival in eligible adults with symptomatic heart failure and reduced ejection fraction following an acute heart attack.

• Help manage high blood pressure where eplerenone is an approved treatment.

  
  

The appropriate treatment and dose should be determined by a healthcare professional based on the patient's condition, kidney function, blood potassium levels and other medicines.

How Does Eplerenone Work?

Eplerenone blocks aldosterone receptors, reducing the hormone's effects on sodium and potassium balance. This helps the body regulate fluid retention and can lower blood pressure.

In patients with eligible forms of heart failure, treatment can improve clinical outcomes. Regular monitoring is necessary because eplerenone can increase blood potassium levels.

How to Take Eplerenone

Take Eplerenone exactly as prescribed by your healthcare professional.

• Frequency: It is generally taken once daily, although the prescribed regimen depends on the condition being treated.

• With food: It can generally be taken with or without food.

• Administration: Swallow the tablet with water.

• Missed dose: Follow the instructions in the patient information leaflet. Do not take a double dose to make up for a missed tablet.

• Monitoring: Attend recommended blood tests to check potassium levels and kidney function.

• Treatment changes: Do not change the dose or stop treatment without consulting your healthcare professional.

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Important Safety Information

Tell your doctor or pharmacist about your medical history and all medicines, vitamins, supplements and herbal products you use.

Eplerenone requires particular caution in people with:

• High blood potassium (hyperkalaemia): Treatment can raise potassium levels further and may affect heart rhythm.

• Kidney impairment: Reduced kidney function increases the risk of potassium accumulation.

• Liver disease: The suitability of treatment depends on the severity of the condition and relevant prescribing guidance.

• Diabetes or other conditions affecting kidney function: These may increase the risk of complications and require closer monitoring.

  
  

Important medicine interactions include:

• Potassium supplements and potassium-containing salt substitutes, which can increase blood potassium levels.

• ACE inhibitors and angiotensin receptor blockers (ARBs), which may increase the risk of hyperkalaemia.

• Other potassium-sparing diuretics, including spironolactone and amiloride.

• Certain antibiotics, antifungals and antiviral medicines, particularly strong CYP3A inhibitors, which can increase eplerenone levels. Some combinations are contraindicated.

• Non-steroidal anti-inflammatory drugs (NSAIDs), which may affect kidney function.

• Lithium and digoxin, which may require additional monitoring when used with eplerenone.

  
  

Check potential interactions and contraindications with your doctor or pharmacist before starting or changing any medicine.

Pregnancy & Breastfeeding

There is limited information about eplerenone use during pregnancy. It should be used only when a healthcare professional considers it necessary after assessing the potential benefits and risks.

It is not known with certainty whether eplerenone passes into human breast milk. If you are pregnant, planning a pregnancy or breastfeeding, discuss the potential risks and treatment options with your doctor or pharmacist.

Side Effects

Like all medicines, Eplerenone can cause side effects, although not everyone experiences them.

Possible side effects include:

• Dizziness

• Headache

• Diarrhoea

• Nausea

• Cough

• Increased blood potassium levels

  
  

Seek prompt medical attention if you experience severe muscle weakness, an irregular heartbeat or fainting, as these may indicate a serious electrolyte disturbance. Seek emergency assistance for signs of a severe allergic reaction, such as difficulty breathing or swelling of the face or throat.

This is not a complete list of side effects or warnings. Please refer to the product packaging and patient information leaflet supplied with your medicine for complete information and speak with your doctor or pharmacist if you have concerns.

Storage

Store Eplerenone according to the instructions shown on the original product packaging.

• Keep the tablets in their original packaging where instructed.

• Follow the storage conditions stated in the product leaflet.

• Keep out of reach of children.

• Do not use the medicine after its expiry date.