Short Description
Biphasic Isophane Insulin 30 Injection is a premixed insulin preparation used to help control blood glucose levels in people with diabetes. It typically combines soluble human insulin, which acts relatively quickly, with isophane (NPH) insulin, which provides a longer-lasting effect. Confirm the exact composition on the product packaging.
What Is Biphasic Isophane Insulin 30 Injection?
Biphasic Isophane Insulin 30 is generally a mixture of 30% soluble human insulin and 70% isophane insulin. The soluble component helps manage rises in blood glucose around meals, while the intermediate-acting component provides insulin activity for a longer period.
It is used as part of a diabetes management plan that may include meal planning, physical activity, and regular blood glucose monitoring. Formulations and delivery devices may vary by manufacturer, so check the product label before use.
Uses
Biphasic Isophane Insulin 30 Injection 100 IU/mL may be prescribed to:
Help control blood glucose levels in people with type 1 diabetes mellitus.
Improve blood glucose control in people with type 2 diabetes mellitus who require insulin therapy.
Provide both meal-related and longer-lasting insulin activity as part of an individualised diabetes management plan.
The appropriate insulin dose and injection schedule must be determined by a healthcare professional based on blood glucose levels, meals, activity, and individual treatment needs.
How Does Biphasic Isophane Insulin 30 Work?
Biphasic Isophane Insulin 30 typically contains 30% soluble human insulin and 70% intermediate-acting isophane insulin. The soluble component helps manage increases in blood glucose after meals, while the isophane component provides a more prolonged glucose-lowering effect.
This combination replaces or supplements insulin that the body cannot produce adequately. It generally begins working within about 30 minutes, although the onset and duration can vary depending on the formulation and individual factors.
How to Take Biphasic Isophane Insulin 30 Injection
Take Biphasic Isophane Insulin 30 Injection exactly as prescribed by your healthcare professional.
Use the injection at the prescribed times, often before meals according to the specific product instructions.
Follow the recommended timing in relation to meals, as the insulin's short-acting component can cause low blood glucose if food intake is delayed or missed.
If the product is a suspension, resuspend it as directed in the manufacturer's instructions before use.
Inject only by the route and with the device specified for your product. Do not inject into a vein.
Rotate injection sites within the recommended areas to reduce the risk of skin changes.
Check your blood glucose as advised by your healthcare professional.
Never change your dose or stop insulin treatment without medical advice.
If you miss a dose, check your diabetes care instructions and contact your healthcare professional for guidance. Do not take an extra dose without advice.
Always check the product leaflet for device-specific instructions and correct injection technique.
Important Safety Information
Tell your doctor or pharmacist about your medical history and all medicines, supplements, and herbal products you use before starting treatment.
Important precautions include:
Low blood glucose (hypoglycaemia): This is a major risk of insulin treatment. Warning signs may include sweating, shaking, hunger, dizziness, palpitations, or confusion.
Kidney or liver problems: These conditions may change insulin requirements and increase the risk of low blood glucose.
Changes in meals or activity: Skipping meals, eating less than usual, or exercising more than usual can affect blood glucose levels.
Illness: Infections, fever, vomiting, or other illnesses can alter insulin requirements. Follow your healthcare professional's sick-day plan.
Injection-site changes: Repeatedly injecting into the same area may cause lumps or changes in the fatty tissue beneath the skin, affecting insulin absorption.
Allergies: Seek medical advice if you have had an allergic reaction to insulin or any ingredient in the formulation.
Medicines that may affect blood glucose or insulin requirements include other diabetes medicines, corticosteroids, some diuretics, certain antidepressants, and some blood pressure medicines. Beta-blockers may also mask some warning signs of low blood glucose. Alcohol can increase the risk of hypoglycaemia.
Check possible interactions with your doctor or pharmacist, and do not adjust your insulin dose without professional guidance.
Pregnancy & Breastfeeding
Insulin may be used during pregnancy when needed to manage diabetes, but insulin requirements can change throughout pregnancy. If you are pregnant or planning a pregnancy, consult your doctor to review your treatment and blood glucose monitoring.
Insulin can generally be used during breastfeeding, although dose requirements may change after delivery or while breastfeeding. Speak with your healthcare professional about monitoring and any necessary treatment adjustments.
Side Effects
Like all medicines, Biphasic Isophane Insulin 30 Injection can cause side effects, although not everyone experiences them.
Possible side effects include:
Low blood glucose, which may cause sweating, shaking, hunger, dizziness, or difficulty concentrating
Weight gain
Redness, itching, or swelling at the injection site
Skin thickening or indentations at injection sites
Temporary swelling or fluid retention
Seek urgent medical attention for severe hypoglycaemia, loss of consciousness, seizures, difficulty breathing, or swelling of the face or throat. Severe low blood glucose may require assistance from another person.
This is not a complete list of side effects or warnings. Please refer to the product packaging and patient information leaflet supplied with your medicine for complete information and speak with your doctor or pharmacist if you have concerns.
Storage
Store Biphasic Isophane Insulin 30 Injection according to the instructions shown on the original product packaging.
Keep unopened insulin refrigerated as directed by the manufacturer; do not freeze it.
Protect the medicine from direct heat and sunlight.
Follow the product-specific instructions for storage after opening or first use, as these vary by presentation.
Keep the injection out of reach of children.
Do not use insulin that has been frozen, is expired, or does not have the appearance described in the product leaflet.