Amlodipine 5mg + Ramipril 5mg Tablets combine two blood pressure-lowering medicines — amlodipine, a calcium channel blocker, and ramipril, an ACE inhibitor — in a single tablet. This combination is used to treat high blood pressure (hypertension) in patients whose condition is already controlled by taking both medicines separately at matching doses.
This tablet contains two active substances: amlodipine, which belongs to a group of medicines called calcium antagonists, and ramipril, which belongs to a group of medicines called ACE inhibitors (Angiotensin Converting Enzyme inhibitors). Each works on blood pressure through a different mechanism.
This fixed-dose combination is generally prescribed as a convenient single-tablet option for patients whose blood pressure is already well managed using amlodipine and ramipril taken as separate tablets at the same respective 5mg doses, rather than as a first-line starting treatment.
Amlodipine 5mg + Ramipril 5mg may be prescribed to:
Treat high blood pressure (hypertension) in patients already stabilised on amlodipine 5mg and ramipril 5mg taken concurrently as separate medicines
The appropriate treatment and dose should be determined by a healthcare professional based on individual health needs.
The two active ingredients act on blood pressure through complementary mechanisms. Ramipril blocks an enzyme involved in producing a substance that narrows blood vessels, helping the vessels relax and easing the workload on the heart. Amlodipine works by relaxing and widening blood vessels directly, allowing blood to flow through them more easily.
Together, these actions support more effective blood pressure control than either medicine alone. Since this combination is generally prescribed once patients are already stabilised on the individual medicines, its effect at this dose is usually established from the start of use, though individual response can vary.
Take Amlodipine + Ramipril exactly as prescribed by your healthcare professional.
Taken once daily, at the same time each day
Can be taken with or without food
Swallow the tablet whole with a drink of water
Avoid grapefruit or grapefruit juice, as it can affect the level of amlodipine in your blood and unpredictably increase the blood pressure-lowering effect
Do not stop or change your dose without medical advice, as your blood pressure may rise again if treatment is stopped without guidance
If you forget a dose, skip it completely and take your next dose at the usual time. Do not take a double dose to make up for a missed one.
Before taking Amlodipine + Ramipril, tell your doctor or pharmacist about your full medical history and all medicines, supplements, and herbal products you currently use.
Caution may be needed if you have, or have had:
Heart, liver, or kidney problems, including reduced blood supply to the kidneys
A recent heart attack, unstable blood pressure, or narrowing of the aortic heart valve
Significant fluid or salt loss (for example, from vomiting, diarrhoea, or long-term diuretic use)
High potassium levels shown on blood tests
A history of angioedema (swelling of the face, lips, tongue, or throat) related to previous ACE inhibitor use
Amlodipine + Ramipril may interact with other blood pressure medicines (including ARBs and aliskiren), certain diuretics, potassium-sparing medicines, NSAIDs, lithium, some antibiotics and antifungals, and sacubitril/valsartan. It is important to check possible interactions with your doctor or pharmacist before starting treatment.
Amlodipine + Ramipril should not be taken during the first 12 weeks of pregnancy and must not be taken from the 13th week onward, as it may cause serious harm to the baby. It is also not recommended while breastfeeding. If you are pregnant, breastfeeding, think you may be pregnant, or are planning a pregnancy, speak with your doctor or pharmacist promptly, as a switch to an alternative treatment is generally needed in advance of a planned pregnancy.
Like all medicines, Amlodipine + Ramipril can cause side effects, although not everyone experiences them.
Common side effects may include:
Fluid retention (swelling, especially of the ankles)
Dizziness or sleepiness, particularly at the start of treatment
Headache or tiredness
Dry, tickly cough
Flushing or palpitations
Low blood pressure, especially when standing up quickly
Digestive symptoms such as stomach pain, diarrhoea, constipation, or nausea
Seek prompt medical attention if you experience swelling of the face, lips, or throat with difficulty breathing or swallowing, severe skin reactions, sudden wheeziness or breathlessness, chest pain, or signs of unusual bleeding or bruising.
This is not a complete list of side effects or warnings. Please refer to the product packaging and patient information leaflet supplied with your medicine for complete information and speak with your doctor or pharmacist if you have concerns.
Store below 30°C
Keep in the original packaging to protect from light
Keep out of reach and sight of children
Do not use after the expiry date shown on the packaging
They lower blood pressure through different mechanisms — a calcium channel blocker and an ACE inhibitor — which can give better control than either medicine alone and simplifies dosing into a single tablet.
Some effect is usually seen within the first couple of weeks, but the full blood-pressure-lowering effect is generally assessed after 3–4 weeks of consistent use.
It replaces taking amlodipine and ramipril as two separate tablets, but it should be taken whole and not split or adjusted without your doctor's guidance.
Ankle swelling is a known effect of amlodipine, the calcium channel blocker component. It's worth mentioning to your doctor if it becomes bothersome.
No. High blood pressure is usually managed on a long-term basis, and stopping suddenly can cause blood pressure to rise again.
Mild dizziness can occur as your body adjusts, especially after the first dose. If it's severe or persistent, contact your doctor.
